Genetics and breast cancer
Introduction
Breast cancer is the second cancers in women common in women. While it is rare cancers in men, it represents only 1% of all people living with breast cancer. In the next lines we will discuss breast cancer a genetic and the role of genes (genes) in the incidence of the disease will not we look at the methods of treatment.
Genetics and cancer
The real reasons and the direct incidence of cancer is not clearly known. But it is considered a genetic disease multiple reasons. It is not produced in the habit of a causal one, but is the product of a confluence of many things and factors. And divide these factors or causes of genetic factors and environmental factors. And genetic factors is a bug or a change in one gene makes a person has a susceptibility to infection if exposed to something in the environment .. any injury that does not occur unless the person has a vulnerability to infection and subjected to a cause in the environment surrounding it.
Genetics and breast cancer
There is no doubt among scientists that breast cancer is a disease that are inherited multiple reasons. Women develop breast cancer if they have a genetic predisposition makes it subject to injury and exposure to something in the surrounding environment. And geneticists are trying to look for genes that make women have a susceptibility and they are interested in the cancer in general the search for environmental causes.
With, we said that breast cancer is transmitted hereditary multiple reasons but there are some families with highly susceptible to infection due to a genetic factor is strong. And thus may be transmitted disease (in the form of Jane) from one generation only the latest. And the geneticists to conduct genetic research on these families to discover new types of genes. and may Tqra in the newspapers a while and the last discovery of a new gene causes breast cancer towards a convergence of efforts to try to discover the real causes of cancer and that may be useful in the discovery of modern methods of cancer prevention or production of new treatments and effective for this malignant disease.
And when repeated breast cancer in the family is not necessarily that such an injury as a result of the existence of genetic factors, and strong in that family. Only be the result of a confluence of many reasons with one another (ie inheritance multiple reasons) or the result of exposure all the injured to carcinogens in environment. Therefore we can say that most patients with breast cancer happened to them cancer due to hereditary factors and environmental with each other. while a few of those infected with genetic factors only, or only environmental. Note that we used the word factor was the transfer of the causes and the reason for this is that the person who wounded cancer had a had prepared from birth for cancer as a result of corruption, defect, or a change in one gene (called the change boom), but this change alone does not cause normally any disease, but with the passage of age or after exposure to something in the environment (some viruses chemical or nuclear-rays) has only hit the second copy of the gene long ago allies cause of his cancer. and therefore it is cancer, breast cancer, including the result of a Tefrtin in a pair of genes, this method is known to doctors strike double.
Discovery of genes for breast cancer
Scientists have the assistance of some families, who repeated their risk of breast cancer to detect some genes that are caused directly in the incidence of this type of cancer. But with all the concerted efforts to uncover the causes of genetics, the work is still in its infancy and only needs further research and cooperation between scientists and the injured this disease or who are vulnerable to injury. and to facilitate understanding of the role and importance of these genes will divide these genes into three groups. in the first group genes have a strong tendency to develop breast cancer if there is the boom or change. represent this group a small percentage of the total cancer patients breast and Sue P call this group gene powerful rare-proliferation. The second group is more common than the first and the genes where strong, and the name of this group of genes a middle-power-proliferation. The last group is more spread than its predecessors, but genes are weak and call it a set of genes vulnerable the most spread.
Rare genes spread
There are rare diseases result from defects in a gene making the patient by his susceptibility to cancer in any part of his body. And called on these diseases, syndromes of the most well known syndrome me Vromagn (Li Frumani Syndrome) is the result of a defect in a gene known so-called Pidgin B 53 (P53 ). and this gene as is the case in many of the genes that cause cancer, it controls cell division and division. and when a surge by the upset this control is produced by the cells divided at random or without the need for, and if not stop this division, then the matter leads to a large block cells from unwanted spoke tumor.
Medium-proliferation genes
This group includes the genes (Morothyn) are important and one of them on chromosome 17 and called Bal breast cancer gene 1 (BRC1) and the second on chromosome 13 called Pidgin breast cancer 2 (BRC2). There are about 200 formula (Aliel Alleles) of the gene, the first and about 100 version of the gene II. but not all of these formulas increases the risk of breast cancer, but every woman with a version of carcinogens have the potential to have up to 80% before reaching age 70. Frequently some versions of carcinogens in some people, for example, 2.5% of the Jews Ali_kinaziin (of European descent, ) have the formula carcinogens, is the leading cause of injury 25% of all cases of breast cancer for women who are aged less than 40 years. but the proportion living with breast cancer gene 1 and 2 in the general public conducted research on them (Europeans, and North America) does not exceed 0.5%, which is the main cause of about 5-10% of cases of breast cancer. There are indications that the existence of Jane's third in this group but have not been disclosed until now. I have recently discovered that the formula of natural breast cancer gene 1 might become a form carcinogenic if there chemical change in the situation of the adjacent part of the gene, and it is not a condition that the change occurs within the gene. called the Take the situation by adding chemicals to DNA Almithalin Situsin (Hyper-Methylation)
The most common genes vulnerable
Scientists know little about this group because of the difficulty to detect. A group are important because of the belief that it the main cause of many cases. The most important gene discovered in this group gene causes the disease known as syndrome Otaxia Tlnczyktezia (Ataxia Telengectasia) affects children and leads to an imbalance in the walking with the expansion in the capillaries of the eyes with an increase in the incidence of cancer of the lymph nodes and it also increases the risk the child's mother to breast cancer. In the near future, God willing, you will discover more and more of these genes, but it is believed that each gene will be responsible for the proportion of small number of cases of breast cancer.
0 commentaires